Agent-Disease Links

 

Section 1 (Sent to NLM in February and March 2008)

 

New Agent-Disease Links 2/23/08

 

These are Agent-Disease links for the 112 agents sent to NLM on February 3. The names of the agents are followed by the ID numbers of the linked diseases. See tables below for names of diseases.

 

No established human carcinogen (occupational): 141, 142, 144, 146, 147, 192, 200, 549;

Other biological toxins: 415, 431

Irritants:249, 285, 563

Hand-arm vibration: 279

Decompression:284

Mercury, inorganic compounds: 333, 18 (This is a new agent. Also, "Mercury" was changed to "Mercury, elemental."

Alizarin complexone: 18

Alizarin: 18

Azo violet: 18

Hydroxynaphthol blue: 18

Methyl purple: 18

Phenol blue: 18

Fungi: 23, 115, 390

Nickel II chloride hexahydrate: 23

Nickel II sulfate hexahydrate: 306, 23, 18

Hydrazine mononitrate: 306, 310, 18

Xenon: 310, 350

Lithium deuteride: 306

Manganese dioxide: 25

Deuterium: 350

Potassium iodide: 18

Urethane: 326

Diethylene glycol dibutyl ether: 326

Krypton: 350

Potassium ferricyanide: 351

1,1-Difluorethane: 326, 350

Quinuclidinyl benzilate: 310

Lanosol yellow 4G: 23

Ammonium bifluoride: 247

Calcium fluoride: 247

Sodium phosphate, tribasic: 306

FD&C blue no. 2: 23

 

New Agent-Disease Links 3/16/08

 

These are Agent-Disease links for the 120 agents sent to NLM on March 16. The names of the agents are followed by the ID numbers of the linked diseases. See tables below for names of diseases.

 

RARE EARTH METALS: 552; 235

Selenium oxychloride: 306; 18

Selenium dioxide: 306; 18

Dimethylmercury: 310

Aldicarb: 66

Acetophenone: 326

SULFITES: 23

Ethylphosphonofluoridic acid isopropyl ester: 66

Cyclohexyl sarin: 66

Mercury II acetate: 333; 18; 

Lead II nitrate: 333; 223

Decahydronaphthalene: 326; 325

Ammonium phosphate, monobasic: 306

1,1,1,2-Tetrafluoroethane: 326; 350

Diseases in Haz-Map 2/23/08 Excluding Infectious Diseases

 

ID Disease Name

Acute Poison

656 Acute tubular necrosis
306 Pneumonitis, toxic
350 Asphyxiation, simple
155 Humidifier fever
326 Solvents, acute toxic effect
82 Hepatitis, chemical
363 Inhalation fever
310 Encephalopathy, acute toxic
351 Asphyxiation, chemical
159 Pontiac fever
158 Mill fever
226 Hemolytic anemia, acute
157 Organic dust inhalation fever
156 Grain fever
154 Polymer fume fever
318 Hydrofluoric acid, toxic effect
390 Hypersensitivity pneumonitis, acute
415 Tick paralysis
66 Organophosphate & carbamates, acute
160 Pentachlorophenol/Dinitrophenol, acute
431 Ciguatera fish poisoning
165 Organochlorine insecticides, acute
210 Methemoglobinemia, acute
389 Fumigants, acute toxic effect
69 Metal fume fever
550 Radiation sickness, acute

Airway

249 Asthma, irritant-induced
255 Byssinosis
551 Bronchiolitis obliterans
23 Asthma, occupational
236 Pulmonary disease, chronic obstructive
420 Vocal cord dysfunction, irritant-associated

Occupational Cancer

192 Kidney cancer
190 Bone cancer
189 Laryngeal cancer
200 Colorectal cancer
140 Nasal sinus cancer
2 Lung cancer
32 Skin cancer
549 Thyroid cancer
548 Melanoma
547 Liver cancer
3 Mesothelioma, pleural
136 Bladder cancer
147 Esophagus cancer
167 Leukemia
141 Nasopharynx cancer
142 Pancreatic cancer
144 Brain cancer
146 Stomach cancer
4 Mesothelioma, peritoneal

Chronic Poison

25 Parkinsonism
21 Sinusitis, chronic
282 Acro-osteolysis
655 Chronic renal failure
426 Carbon disulfide, chronic toxic effect
333 Neuropathy, toxic
325 Encephalopathy, chronic solvent
308 Cataract, chemical or radiation induced
9 Aplastic anemia
284 Osteonecrosis
281 Osteomalacia
279 Raynaud, phenomenon of
247 Skeletal fluorosis
307 Infertility, male

Interstitial 

1 Asbestosis
26 Chronic beryllium disease
552 Pneumoconioses, other
423 Asbestos-related pleural disease
235 Pneumoconioses, benign
117 Coal workers, pneumoconiosis of
118 Silicosis, simple
256 Hard metal disease
257 CWP, complicated
259 Silicosis, complicated
260 Silicosis, acute
115 Hypersensitivity pneumonitis, chronic

Metals

6 Cadmium, chronic toxic effect
13 Mercury, elemental, chronic toxic effect
17 Chromium, chronic toxic effect
36 Arsenic, chronic toxic effect
223 Lead, subacute toxic effect
239 Manganese, chronic toxic effect

Skin

18 Contact dermatitis, allergic
175 Oil acne
266 Contact urticaria
267 Contact dermatitis, photoallergic
285 Contact dermatitis, photoirritant
563 Contact dermatitis, irritant
215 Chloracne

Diseases Sorted by ID Number

ID Disease Name
1 Asbestosis
2 Lung cancer
3 Mesothelioma, pleural
4 Mesothelioma, peritoneal
6 Cadmium, chronic toxic effect
9 Aplastic anemia
13 Mercury, elemental, chronic toxic effect
17 Chromium, chronic toxic effect
18 Contact dermatitis, allergic
21 Sinusitis, chronic
23 Asthma, occupational
25 Parkinsonism
26 Chronic beryllium disease
32 Skin cancer
36 Arsenic, chronic toxic effect
66 Organophosphate & carbamates, acute
69 Metal fume fever
82 Hepatitis, chemical
115 Hypersensitivity pneumonitis, chronic
117 Coal workers, pneumoconiosis of
118 Silicosis, simple
136 Bladder cancer
140 Nasal sinus cancer
141 Nasopharynx cancer
142 Pancreatic cancer
144 Brain cancer
146 Stomach cancer
147 Esophagus cancer
154 Polymer fume fever
155 Humidifier fever
156 Grain fever
157 Organic dust inhalation fever
158 Mill fever
159 Pontiac fever
160 Pentachlorophenol/Dinitrophenol, acute
165 Organochlorine insecticides, acute
167 Leukemia
175 Oil acne
189 Laryngeal cancer
190 Bone cancer
192 Kidney cancer
200 Colorectal cancer
210 Methemoglobinemia, acute
215 Chloracne
223 Lead, subacute toxic effect
226 Hemolytic anemia, acute
235 Pneumoconioses, benign
236 Pulmonary disease, chronic obstructive
239 Manganese, chronic toxic effect
247 Skeletal fluorosis
249 Asthma, irritant-induced
255 Byssinosis
256 Hard metal disease
257 CWP, complicated
259 Silicosis, complicated
260 Silicosis, acute
266 Contact urticaria
267 Contact dermatitis, photoallergic
279 Raynaud, phenomenon of
281 Osteomalacia
282 Acro-osteolysis
284 Osteonecrosis
285 Contact dermatitis, photoirritant
306 Pneumonitis, toxic
307 Infertility, male
308 Cataract, chemical or radiation induced
310 Encephalopathy, acute toxic
318 Hydrofluoric acid, toxic effect
325 Encephalopathy, chronic solvent
326 Solvents, acute toxic effect
333 Neuropathy, toxic
350 Asphyxiation, simple
351 Asphyxiation, chemical
363 Inhalation fever
389 Fumigants, acute toxic effect
390 Hypersensitivity pneumonitis, acute
415 Tick paralysis
420 Vocal cord dysfunction, irritant-associated
423 Asbestos-related pleural disease
426 Carbon disulfide, chronic toxic effect
431 Ciguatera fish poisoning
547 Liver cancer
548 Melanoma
549 Thyroid cancer
550 Radiation sickness, acute
551 Bronchiolitis obliterans
552 Pneumoconioses, other
563 Contact dermatitis, irritant
655 Chronic renal failure
656 Acute tubular necrosis

 

 

Mapping Rules for Lead Compounds

 

All lead compound are linked to 223  (Lead Poisoning) and are also linked to a neurological disease, either 310 (Acute Toxic Encephalopathy) for organic lead compounds or 333 (Toxic Neuropathy) for other lead compounds. Organic lead compounds are also linked to 226 (Acute Hemolytic Anemic). All lead compounds are also linked to the Adverse Effects: Secondary Hepatotoxin, Reproductive Toxin, and Nephrotoxin.

 

Lead: 223, 226, 307, 333, 655, 656

Lead chromate: 223, 333

Lead arsenate: 223, 333

Lead IV oxide: 223, 333

Lead II sulfate: 223, 333

Lead II nitrate: 223, 333

Tetraethyl lead: 223, 226, 310 (Deleted 307)

Tetramethyl lead: 223, 226, 310 (Deleted 307)

Lead azide: 223, 333

Lead II thiocyanate: 223, 333

Lead nitroresorcinate: 223, 333

Lead styphate: 223, 333

Lead II acetate trihydrate: 223, 333

 

Changes Made in Review of "Health Hazard Summaries

 for Industrial and Occupational Chemicals" [Olson, Table IV-4]

 

Benzonitrile: 160, delete 351

Bromine pentafluoride: 247

p-Dichlorobenzene: 310

2-Diethylaminoethanol: 18

Dinitro-o-cresol: 160

Dinitrophenol: 160

4,6-Dinitro-o-sec-butyl phenol: 160

Dinocap: 160

2.4-Dinitrophenol:160

Diglycidyl ether: 18, 306

Epichlorohydrin: 306

2-Ethylaminoethanol: 18

Ethylene dichloride: delete 306

Ethyl silicate: 326

Furfural: 310

Glycidol: delete 18

Iodine: 306

Oxalic acid: 306

Oxygen difluoride: 247

Mercury, elemental: delete 18

Petroleum gas (liquified): 326

Propylene oxide: 306, 310

Methylamine: 306

Sodium azide: 306

Styrene: delete 18

Tellurium and compounds: 310

 

Additions Made in Review of Kidney Diseases

 

1,4-Dioxane: 656

Arsine: 656

Cadmium and compounds: 656, 655

Carbon tetrachloride: 656

Chromium and compounds: 656

Dinitro-o-cresol: 656

Dinitrophenol: 656

Diquat: 656

Lead: 656, 655

Mercury, elemental: 655

Paraquat dichloride: 656

Pentachlorophenol: 656

Stibine: 656

Uranium and compounds: 656

 

Review of 663 Chemicals Added to Haz-Map Sometime in the 1990s

Completed March 8, 2008

New Links Added to Group I (First 110 Chemicals)

Acrylic acid: 306

Hexachloroethane: 310

Nitric oxide: 306

New Links Added to Group II (Second 110 Chemicals)

Boron trifluoride: 247

Bromine pentafluoride: 247

n-Butane: 350

tert-Butyl chromate: 310

Camphor, synthetic: 310

Caprolactam: 310

Catechol: 310

alpha-Chloroacetophenone: 306

bis-Chloromethyl ether: 306

Chloromethyl methyl ether: 306

Chromyl chloride: 306

Vinyl bromide: 326

Vinyl fluoride: 326

Vinylidene chloride: 326

New Links Added to Group III (Third 110 Chemicals)

2-Nitropropane: 326

1,3-Dichloro-5,5-dimethylhydantoin: 306

Diethyl ketone: 325

o-Dichlorobenzene: 325

Ethyl butyl ketone: 325

Ethylidene norbornene: 326

Formamide: 326

Isobutyl acetate: 325

N-Isopropylaniline: 18

p-Toluidine: 18

Vinyl cyclohexene dioxide: 306

New Links Added to Group IV (Fourth 110 Chemicals)

Dimethylaminopropionitrile: 333

Methyl acetylene-propadiene mixture: 326; 325

Methylcyclohexanol: 325

Morpholine: 306

Nitroethane: 326

Nitrogen trifluoride: 247

1-Nitropropane: 326; 325

Nonane: 325

Oxygen difluoride: 247

Phenylphosphine: 226

Phosphoric acid: 306

Thioglycolic acid: 306

New Links Added to Group V (Fifth 110 Chemicals)

N,N-Dimethyl-1,3-propanediamine: 306

Hexachlorophene: 18; 310

p-Nitrochlorobenzene: 18

4-Nitrophenol: 18

Sodium fluoride: 247

Sulfur tetrafluoride: 247

Triethylene tetramine: 306

New Links Added to Group VI (Last 113 Chemicals)

Benzotriazole: 18

Benzylamine: 306

Bithionol: 18; 267

Boron trifluoride etherate: Delete 326

1-Bromo-2-propanol: 326

Butylated hydroxyanisole: 23

Chloramide: Delete 23

Dichlorophen: 18

Ethyl lactate: 326; 325

Ethyl-3-ethoxypropionate: 326

Fentichlor: 267

Tetramethyl ammonium hydroxide: 306

Triclosan: 18; 267

 

Change of Links to Chronic Solvent Encephalopathy (ID 325)

 

Instead of the previous rule of linking to all agents tagged with the adverse effect "Solvent Syndrome," this disease is now linked with all chemicals that are so tagged AND they are also linked to the Process "Painting (Solvents)." Any other chemicals, such as Styrene, with strong epidemiologic evidence of association with chronic solvent syndrome will also be linked to this disease. The following table shows all chemicals linked to Acute Solvent Syndrome. Chemicals that are also linked to Chronic Solvent Encephalopathy are shown in bold.

 

1,1,1,2-Tetrachloro-2,2-difluoroethane

1,1,1,2-Tetrachloroethane

1,1,1,2-Tetrafluoroethane

1,1,1-Trichloroethane

1,1,2,2-Tetrabromoethane

1,1,2,2-Tetrachloro-1,2-difluoroethane

1,1,2,2-Tetrachloroethane

1,1,2-Trichloro-1,2,2-trifluoroethane

1,1,2-Trichloroethane

1,1-Dichloroethane

1,1-Difluoroethane

1,2,3,4-Tetrahydronaphthalene

1,2,3-Trichloropropane

1,2,4,5-Tetrachlorobenzene

1,2,4-Trichlorobenzene

1,2-Dichloroethylene, all isomers

1,3-Dichloropropene

1,3-Dioxolane

1,4-Dioxane

1-Bromo-2-propanol

1-Bromopropane

1-Hexanol

1-Hexene

1-Nitropropane

2,2-Dimethylbutane

2-Butanone

2-Butoxyethanol

2-Butoxyethyl acetate

2-Ethoxyethanol

2-Ethoxyethyl acetate

2-Isopropoxyethanol

2-Methoxyethanol

2-Nitropropane

4-Vinyl cyclohexene

Acetone

Acetophenone

Acetyl acetone

Acetylene

alpha-Methyl styrene

Benzene

Benzyl acetate

Bromobenzene

Bromoform

Butyrolactone

Carbon tetrabromide

Carbon tetrachloride

CHLORINATED SOLVENTS

Chlorobenzene

Chlorobromomethane

Chlorodifluoromethane

CHLOROFLUOROCARBONS

Chloroform

Chloropentafluoroethane

Chloropropanol

Chlorotrifluoromethane

Collodion

Cumene

Cycloheptane

Cyclohexane

Cyclohexanol

Cyclohexanone