Methyl isoamyl ketone
Agent Name
Methyl isoamyl ketone
CAS Number
110-12-3
Formula
C7-H14-O
Major Category
Solvents
Synonyms
2-Hexanone, 5-methyl-; 2-Methyl-5-hexanone; 5-Methyl-2-hexanone; Isoamyl methyl ketone; Isopentyl methyl ketone; Ketone, methyl isoamyl; MIAK; Methyl isoamyl ketone; Methyl isopentyl keton; [ChemIDplus] 5-Methylhexan-2-one; [CAMEO] UN2302
Category
Ketones (<C12)
Description
Colorless, clear liquid with a pleasant, fruity odor; [NIOSH]
Sources/Uses
Used as a solvent for nitrocellulose, cellulose acetate, butyrate, acrylics, high-solid coatings, and vinyl copolymers; [HSDB]
Comments
A skin and eye irritant; [CAMEO] Inhalation of high concentrations may cause kidney injury and unconsciousness; [ICSC] Causes liver injury after repeated high-dose inhalation exposures of rats; [HSDB]
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
20 ppm
STEL (ACGIH)
50 ppm
PEL (OSHA)
100 ppm
MAK
10 ppm
Vapor Pressure
5.77 mm Hg
Odor Threshold Low
0.01 ppm
Odor Threshold High
0.04 ppm
Lethal Concentration
LC50 (rat) = 3,813 ppm/6h
Explanatory Notes
Detection odor threshold from AIHA (mean = 0.013 ppm); Flash point = 36 deg C; VP from HSDB;
NFPA
may ignite at ambient temp
Adverse Effects
Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Nephrotoxin
Yes
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: