Isoxathion

Synonyms

E-48; Isoxathion [BSI:JMAF:ISO]; Karphos; O,O-Diethyl O-(3-(5-phenyl)-1,2-isoxazolyl)phosphorothionate; O,O-Diethyl O-(5-phenyl-3-isoxazolyl) phosphorothioate; SI-6711; Phosphorothioic acid, O,O-diethyl O-(5-phenyl-3-isoxazolyl) ester; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Yellowish liquid; [HSDB]

Sources/Uses

Used as contact and stomach insecticide for fruits, tea, tobacco, ornamentals, rice, sugarcane, vegetables, turf, and trees; [HSDB]

Comments

“The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

No longer registered as a pesticide for use in the US; [HSDB] Banned in the EU for use as pesticide for plant protection; [eChemPortal: ESIS]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

2.22E-06 mm Hg

LC50 (rat) = 4,200 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)