Methanesulfonyl fluoride

Agent Name
Methanesulfonyl fluoride
CAS Number
558-25-8
Formula
C-H3-F-O2-S
Major Category
Toxic Gases & Vapors
Methanesulfonyl fluoride formula graphical representation
Synonyms
Fluoro methyl sulfone; Fumette; MSF; Mesyl fluoride; Methanesulphonyl fluoride; [ChemIDplus] UN2927
Category
Acid Halides
Description
Liquid; [CAMEO] Colorless liquid with a pungent odor; [MSDSonline]
Sources/Uses
Used formerly as fumigant insecticide; Used in medical research; [HSDB]
Comments
Highly corrosive; May cause serious injury to skin, eyes, mucous membranes, and upper respiratory tract; Inhalation may cause chemical pneumonitis and pulmonary edema; A selective inhibitor of CNS acetylcholinesterase; Sex-specific changes in brain development were observed in rats chronically exposed in utero; [HSDB] Reacts with water evolving hydrogen fluoride gas; Corrosive; Highly toxic by inhalation; [CAMEO] Effects in high-dose animal studies include inhibition of true cholinesterase and degenerative changes to brain; [RTECS]
Biomedical References

Exposure Assessment

BEI
Fluorides in urine = 2 mg/L prior to shift or 3 mg/L at end of shift; (Repeated measurements recommended.)
TLV (ACGIH)
2.5 mg/m3, as F
PEL (OSHA)
2.5 mg/m3, as F
MAK
1 mg/m3, as F, inhalable fraction
Vapor Pressure
10.9 mm Hg
Lethal Concentration
LC50 (rat) = 1 ppm/7h
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxic liquid, corrosive, organic, n.o.s. (Inhalation Hazard Zone A)." VP from ChemIDplus;

Adverse Effects

Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns

Diseases, Processes, and Activities Linked to This Agent

Processes

Industrial Processes with risk of exposure: