Omethoate

Synonyms

2-Dimethoxyphosphinoylthio-N-methylacetamide; Acetamide, 2-mercapto-N-methyl-, S-ester with O,O-dimethyl phosphorothioate; BAY 45432; Bayer 45,432; Bayer S-6876; Dimethoate O-analog; Dimethoate PO isologue; Dimethoate oxygen analog; Dimethoate-met; Dimethoxon; Dimethyl-S-(N-methyl-carbamoyl-methyl)phosphorothiolate; ENT 25,776; Folimat; O,O-Dimethyl S-((methylcarbamoyl)methyl)phosphorothioate; O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl) phosphorothioate; O,O-Dimethyl S-(2-(methylamino)-2-oxoethyl)phosphorothioate; O,O-Dimethyl S-(N-methylcarbamoylmethyl) phosphorothiolate; O,O-Dimethyl S-(N-methylcarbamoylmethyl) thiophosphate; O,O-Dimethyl S-methylcarbamoylmethyl phosphorothioate; O,O-Dimethyl phosphorothioate S-ester with 2-mercapto-N-methylacetamide; O,O-Dimethyl-S-((N-methyl-carbamoyl)-methyl)-monothiofosfaat [Dutch]; O,O-Dimethyl-S-(2-oxo-3-azabutyl)-monothiophosphate; O,O-Dimethyl-S-(N-methyl-carbamoyl)-methyl-monothiophosphat [German]; O,O-Dimethyl-S-(N-methyl-carbamoyl-methyl)-thiolphosphat [German]; O,O-Dimethyl-S-(N-methylcarbamoylmethyl)phosphorothioate; O,O-Dimetil-S-(N-metil-carbamoil)-metil-monotiofosfato [Italian]; O-Analog of dimethoate; Omethoat; P=O-Rogor; PO-Dimethoate; Phosphorothioic acid, O,O-dimethyl S-(2-(methylamino)-2-oxoethyl) ester; S-6876; S6876; Thiophosphate de O,O-dimethyle et de S-(N-methylcarbamoyl) methyle [French]; Phosphorothioic acid, O,O-dimethyl ester, S-ester with 2-mercapto-N-methylacetamide; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Colorless to yellow oily liquid; [HSDB]

Sources/Uses

"This chemical ingredient is not found in any products." [NPIRS] The major metabolite of dimethoate; Has been used as an insecticide in vegetable and forage crops to control aphids and red spider mites; Has active international registrations; [HSDB]

Comments

A small number of the organophosphates (OPs) can Induce Delayed Neuropathy (OPIDN). OPIDN usually occurs after ingestion and is usually nonoccupational. [Levy, p. 431] Allergic contact dermatitis reported in farmworkers; [Kanerva, p. 781] Contact dermatitis is rare. [Kanerva, p. 1783] The major degradate/metabolite and oxygen analog of dimethoate; More toxic than dimethoate; A potent cholinesterase inhibitor; [Reference #1] May cause irritation; A highly toxic cholinesterase inhibitor; Readily absorbed through skin; Toxic by ingestion; Targets CNS, heart, blood, and eyes; [Aldrich MSDS] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs] See "Dimethoate."

Not registered for use in the US, but has active registrations internationally; [Reference #1]

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

2.48E-05 mm Hg

LC50 (rat) > 1,500 mg/m3/1hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Yes

Predominantly motor

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)