Endothion

Synonyms

5-Methoxy-2-(dimethoxyphosphinylthiomethyl) pyrone-4; 5-Methoxy-2-(dimethoxyphosphinylthiomethyl)pyrone-4; 7175 RP; AC-18,737; ENT 24,653; Endocid; Endocide; Exothion; FMC 5767; NIA-5767; Niagara 5767; O,O-Dimethyl S-(5-methoxypyronyl-2-methyl) thiophosphate; O,O-Dimethyl phosphorothioate S-ester with 2-(mercaptomethyl)-5-methoxy-4H-pyran-4-one; O,O-Dimethyl-S-((5-methoxy-pyron-2-yl)-methyl)-thiolphosphat [German]; Phosphate 100; Phosphopyron; Phosphopyrone; Phosphorothioic acid, O,O-dimethyl ester, S-ester with 2-(mercaptomethyl)-5-methoxy-4H-pyran-4-one; Phosphorothioic acid, S-((5-methoxy-4-oxo-4H-pyran-2-yl)methyl) O,O-dimethyl ester; S-((5-Methoxy-4-oxo-4H-pyran-2-yl)methyl) O,O-dimethyl phosphorothioate; S-((5-Methoxy-4H-pyron-2-yl)-methyl)-O,O-dimethyl-monothiofosfaat [Dutch]; S-((5-Methoxy-4H-pyron-2-yl)-methyl)-O,O-dimethyl-monothiophosphat [German]; S-((5-Metossi-4H-piron-2-IL)-metil)-O,O-dimetil-monotiofosfato [Italian]; S-(5-Methoxy-4-pyron-2-ylmethyl) dimethyl phosphorothioate; S-(5-Methoxy-4-pyron-2-ylmethyl) dimethyl phosphorothiolate; S-5-Methoxy-4-oxopyran-2-ylmethyl dimethyl phosphorothioate; S-5-Methoxy-4-pyron-2-ylmethyl O,O-dimethyl phosphorothioate; Thiophosphate de O,O-dimethyle et de S-((5-methoxy-4-pyronyl)-methyle) [French]; [ChemIDplus] UN2783

Category

Organophosphate Insecticides

Description

Solid; [HSDB]

Sources/Uses

Used as aphicide and acaricide in orchards and field crops; Not commercially sold in the US or Canada; Likely discontinued for pesticide use worldwide; [HSDB]

Comments

A cholinesterase inhibitor; [Hawley] No adverse effects observed in 7-day feeding study of rats at 50 ppm; [HSDB] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

5.69E-06 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, solid, toxic."

must be preheated

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)