Iodoform
Agent Name
Iodoform
CAS Number
75-47-8
Formula
C-H-I3
Major Category
Other Uses
Synonyms
Carbon triiodide; Dezinfekt V; Jodoform [Czech]; Methane, triiodo-; Triiodomethane; Trijodmethane [Czech]; [ChemIDplus]
Category
Pharmaceuticals
Description
Yellow to greenish-yellow powder or crystalline solid with a pungent, disagreeable odor. [antiseptic for external use]; [NIOSH]
Sources/Uses
Used as a disinfectant and veterinary antiseptic; [Merck Index, #5033]
Comments
Cases of CNS depression, delirium, and hallucinations were reported when iodoform was used as a topical antiseptic and absorbed through the wound. It causes severe liver injury in animal experiments. 2021 TLV Basis: thyroid effects and fetal/neonatal damage; [ACGIH] See "Iodine" for the TLV of Iodides.
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
0.001 ppm, as elemental iodine, inhalable fraction and vapor
Vapor Pressure
0.04 mm Hg
Odor Threshold Low
1.9E-05 ppm
Odor Threshold High
1.1 ppm
Lethal Concentration
LC50 (rat) = 165 ppm/7h
Explanatory Notes
Odor threshold from AIHA;
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
ACGIH Carcinogen
Not Classifiable
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: