Isopropyl acetate

Synonyms

1-Methylethyl acetate; 2-Acetoxypropane; 2-Propyl acetate; Acetate d'isopropyle [French]; Acetic Acid, isopropyl ester; Acetic acid, 1-methylethyl ester; Isopropile (acetato di) [Italian]; Isopropyl (acetate d') [French]; Isopropyl acetate; Isopropyl ethanoate; Isopropylacetaat [Dutch]; Isopropylacetat [German]; Isopropyle (acetate d') [French]; Isopropylester kyseliny octove [Czech]; Paracetat; [ChemIDplus] UN1220

Category

Esters (<C12)

Description

Colorless liquid with a fruity odor; [NIOSH]

Sources/Uses

Used as a solvent and flavoring agent; [ACGIH] Solvent uses include nitrocellulose, resins, paints, lacquers, inks, insecticides, and perfumes; [Hawley]

Comments

A skin, eye, and respiratory tract irritant; Inhalation of high concentrations far above the OEL can cause CNS depression; [ICSC]

Biomedical References

250 ppm

100 ppm

1800 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the UCC [1970] report that a 4­hour exposure to 16,000 ppm killed 1 of 6 rats. . . . Other animal data: It has been stated that isopropyl acetate is comparable in toxicity to ethyl acetate and n­propyl acetate [ACGIH 1991]. \ Human data: None relevant for use in determining the revised IDLH.

60.4 mm Hg

0.5 ppm

Odor Threshold High

34 ppm

LC50 (rat) = 50,600 mg/m3/8H

Explanatory Notes

IDLH = 10% LEL; Detection odor threshold from AIHA (mean = 4.1 ppm); Flash point = 2 deg C; VP from HSDB; TLVs withdrawn; see Propyl acetate isomers; [ACGIH]

may ignite at ambient temp

Acute solvent syndrome

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Painting (Solvents)
• Plastic Composites Manufacturing