Demeton-S

Synonyms

Demetonthiol; Diethyl S-(2-ethioethyl)thiophosphate; Ethanethiol, 2-(ethylthio)-, S-ester with O,O-diethyl; phosphorothioate; IS [Pesticide]; Isodemeton; Isosystox; Izosystox [Czech]; Mercaptofos teolovy [Russian]; O,O-Diaethyl-S(2-aethylthio-aethyl)-monothiophosphat [German]; O,O-Diethyl S-(2-(ethylthio)ethyl) phosphorothiolate; O,O-Diethyl S-(2-eththioethyl)phosphorothioate; O,O-Diethyl S-2-(ethylthio)ethyl phosphorothioate; O,O-Diethyl S-ethyl-2-ethylmercaptophosphorothiolate; O,O-Diethyl-S-(2-ethylthio-ethyl)-monothiofosfaat [Dutch]; O,O-Dietil-S-(2-etiltio-etil)-monotiofosfato [Italian]; O,O-Dietyl-S-2-etylmerkaptoetyltiofosfat [Czech]; PO-Systox; Phosphorothioic acid, O,O-diethyl S-(2-(ethylthio)ethyl) ester; Thiol systox; Thioldemeton; Thiophosphate de O,O-diethyle et de S-(2-ethylthio-ethyle) [French]; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Colorless liquid; [ICSC] Liquid with an unpleasant odor; May be decomposed by light and air; [MSDSonline]

Sources/Uses

Formerly used as an insecticide; [HSDB]

Comments

A cholinesterase inhibitor that may cause CNS effects resulting in convulsions and respiratory depression; Can be absorbed through skin; [ICSC] Effects in high-dose animal studies include inhibition of cholinesterase activity and decreased growth rate, but no histological changes; [HSDB] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs]

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

0.000262 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)