N-Methylformamide

Agent Name
N-Methylformamide
CAS Number
123-39-7
Formula
C2-H5-N-O
Major Category
Solvents
N-Methylformamide formula graphical representation
Synonyms
EK 7011; Formic acid amide, N-methyl-; Methylformamide; Monomethylformamide; N-Methyl formamide; X 188; Formamide, N-methyl-; [ChemIDplus] MMF; [HSDB]
Category
Amides (<C10)
Description
Colorless liquid; [ICSC] Pale yellow or colorless liquid; [Alfa Aesar MSDS]
Sources/Uses
Used to make pesticides and methyl isocyanate and as an extraction solvent for aromatic hydrocarbons; [HSDB] Photodegradation product of Fluridone (herbicide) and metabolite of dimethylformamide (CAS# 68-12-2); [REPROTOX]
Comments
An eye irritant; May cause liver injury; [ICSC] TLV Basis: Embryo/fetal injury; teratogenic effects; liver injury; "A more recent phase I study using oral administration of NMF found elevated hepatic enzymes, mild myelosuppression and worsening of preexistent toxic peripheral neuropathies at 700 mg/m2 (227 mg/kg);" [ACGIH] An eye irritant; May cause liver injury; Peripheral neuropathy has been observed in patients during clinical trials; Teratogenic and embryotoxic; Emergency treatment: "Dimethylformamide"; [HSDB] An eye, mucous membrane, and upper respiratory tract irritant; Can be absorbed through skin; May cause temporary nervous system depression and liver damage; [CAMEO] Irritating to rabbit eyes; Dramatically reduced body weights and increased liver enzymes in 2-week inhalation study of rats at highest dose (970 mg/m3); In rats fed by gavage, over 50% of fetuses malformed at the highest dose tested (75 mg/kg/day), a maternally toxic dose; Similar results obtained in study of rabbits; [EPA HPV] Causes hepatitis in five-day, intermittent, intravenous study of dogs; [RTECS] Embryotoxic in animals at doses maternally toxic; [REPROTOX] An irritant; [Alfa Aesar MSDS] See "Dimethylformamide."
Biomedical References

Exposure Assessment

TLV (ACGIH)
1 ppm
Vapor Pressure
0.253 mm Hg
Lethal Concentration
LC50 (rat) > 10,760 mg/m3/4hr
Explanatory Notes
VP from ChemIDplus;

Adverse Effects

Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Reproductive Toxin
Yes

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: