N-Methylformamide

Synonyms

EK 7011; Formic acid amide, N-methyl-; Methylformamide; Monomethylformamide; N-Methyl formamide; X 188; Formamide, N-methyl-; [ChemIDplus] MMF; [HSDB]

Category

Amides (<C10)

Description

Colorless liquid; [ICSC] Pale yellow or colorless liquid; [Alfa Aesar MSDS]

Sources/Uses

Used to make pesticides and methyl isocyanate and as an extraction solvent for aromatic hydrocarbons; [HSDB] Photodegradation product of Fluridone (herbicide) and metabolite of dimethylformamide (CAS# 68-12-2); [REPROTOX]

Comments

An eye irritant; May cause liver injury; [ICSC] TLV Basis: Embryo/fetal injury; teratogenic effects; liver injury; "A more recent phase I study using oral administration of NMF found elevated hepatic enzymes, mild myelosuppression and worsening of preexistent toxic peripheral neuropathies at 700 mg/m2 (227 mg/kg);" [ACGIH] An eye irritant; May cause liver injury; Peripheral neuropathy has been observed in patients during clinical trials; Teratogenic and embryotoxic; Emergency treatment: "Dimethylformamide"; [HSDB] An eye, mucous membrane, and upper respiratory tract irritant; Can be absorbed through skin; May cause temporary nervous system depression and liver damage; [CAMEO] Irritating to rabbit eyes; Dramatically reduced body weights and increased liver enzymes in 2-week inhalation study of rats at highest dose (970 mg/m3); In rats fed by gavage, over 50% of fetuses malformed at the highest dose tested (75 mg/kg/day), a maternally toxic dose; Similar results obtained in study of rabbits; [EPA HPV] Causes hepatitis in five-day, intermittent, intravenous study of dogs; [RTECS] Embryotoxic in animals at doses maternally toxic; [REPROTOX] An irritant; [Alfa Aesar MSDS] See "Dimethylformamide."

Biomedical References

1 ppm

0.253 mm Hg

LC50 (rat) > 10,760 mg/m3/4hr

Explanatory Notes

VP from ChemIDplus;

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)