Triethylene glycol monomethyl ether

Synonyms

2-(2-(2-Methoxyethoxy)ethoxy)ethanol; 3,6,9-Trioxa-1-decanol; Dowanol TMAT; Ethanol, 2-(2-(2-methoxyethoxy)ethoxy)-; Methoxytriethylene glycol; Methoxytriglycol; Methyl triethylene glycol; Methyltrioxitol; Poly-Solv TM; Triethylene glycol methyl ether; Triethylene glycolmonomethyl ether; Triglycol monomethyl ether; [ChemIDplus] TGME; [eChemPortal: SIDSUNEP]

Category

Glycol Ethers (E Series)

Description

Colorless liquid; [HSDB] Odorless; [CAMEO]

Sources/Uses

Used as coupling solvent (water-based paints), for blending brake and hydraulic fluids, and as a plasticizer and wetting agent (resins and paints); [HSDB] Used as raw material for automotive hydraulic brake fluids and a solvent in coatings, printing inks, cleaning products, cutting oils, and deicing agents; [eChemPortal: SIDSUNEP]

Comments

In lethal-dose animal studies, causes liver injury; Oral doses of 4000 mg/kg/day for 91 days cause testicular injury in rats; Developmental toxicity is seen in rats receiving >1000 mg/kg/day; Genotoxic studies were negative; [OECD SIDS: 2-(2-(2-Methoxyethoxy)ethoxy)ethanol - 1996] No listed effects of short-term or long-term exposure; [ICSC] May form unstable peroxides in the presence of oxygen; [CAMEO] May cause mild skin and eye irritation; [eChemPortal: SIDSUNEP] See "GLYCOL ETHERS."

Biomedical References

50 mg/m3. inhalable fraction

0.0035 mm Hg

Explanatory Notes

VP from ChemIDplus;

must be preheated

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Metal Machining
• Painting (Solvents)