Hexahydrophthalic anhydride, all isomers
Agent Name
Hexahydrophthalic anhydride, all isomers
CAS Number
85-42-7
Formula
C8-H10-O3
Major Category
Plastics & Rubber
Synonyms
1,2-Cyclohexanedicarboxylic acid anhydride; Araldite HT 907; HHPA; Hexahydrophthalic acid anhydride; Lekutherm Hardener H;1,3-Isobenzofurandione, hexahydro-; Cyclohexane-1,2-dicarboxylic anhydride; [ChemIDplus]
Category
Acid Anhydrides, Cyclic
Description
Solid; [ICSC] Glassy solid; [EPA ChAMP] White solid; [Alfa Aesar MSDS]
Sources/Uses
Used as a curing agent for epoxy resins and an intermediate for plasticizers and other chemicals; [Hawley] Used in the chemical, polymers, and paints, lacquers, and varnishes industries; [IUCLID]
Comments
Occupational asthma reported in chemical worker; [Malo] Toxic by inhalation; A strong skin and eye irritant; [Hawley] Slowly decomposed by water forming acids; A skin and severe eye irritant; May cause skin sensitization and asthma; [ICSC] Workers with occupational contact urticaria, rhinitis, and conjunctivitis from airborne exposure had resolution of symptoms after removal from work. [ACGIH] A skin sensitizer in guinea pig maximization test; Hypersensitivity effects of human exposure include asthma, urticaria, contact dermatitis, hemolysis, and late respiratory systemic syndrome; Allergic asthma is reportedly the major hypersensitivity reaction, with most cases apparently of the IgE form; [IUCLID] Several studies have shown respiratory sensitization in humans; Mildly irritating to skin and severely irritating or corrosive to eyes of rabbits; [EPA ChAMP] An irritant that may cause serious eye injury; May cause sensitization by skin contact and inhalation; [Alfa Aesar MSDS] See "ACID ANHYDRIDES." See "Trimellitic anhydride."
Reference Link #1
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
No
Ceiling (ACGIH)
0.005 mg/m3, inhalable fraction and vapor
Vapor Pressure
0.0535 mm Hg
Lethal Concentration
LC50 (rat) > 1,100 mg/m3/4hr
Explanatory Notes
VP from HSDB;
Adverse Effects
Anemia
Hemolytic anemia
Skin Sensitizer
Yes
Asthma
Yes
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: