Hexachlorophene

Agent Name
Hexachlorophene
CAS Number
70-30-4
Formula
C13-H6-Cl6-O2
Major Category
Other Uses
Hexachlorophene formula graphical representation
Synonyms
2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane; 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane; 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane; 2,2'-Methylenebis(3,4,6-trichlorophenol); AT 7; Acigena; Almederm; Armohex; At-17; B & b Flea Kontroller for Dogs Only; B 32 (VAN); B32; Bilevon; Bis(2-hydroxy-3,5,6-trichlorophenyl)methane; Bis(3,5,6-trichloro-2-hydroxyphenyl)methane; Bis-2,3,5-trichloro-6-hydroxyfenylmethan [Czech]; Blockade Anti Bacterial Finish; Brevity Blue Liquid Bacteriostatic Scouring Cream; Brevity Blue Liquid Sanitizing Scouring Cream; Compound G-11; Cotofilm; Dermadex; Distodin; En-Viron D Concentrated Phenolic Disinfectant; Enditch Pet Shampoo; Esaclorofene [DCIT]; Exofene; Fesia-sin; Fomac; Fostril; G-11; G-Eleven; G-II; Gamophen; Gamophene; Germa-medica; HCP; Hexabalm; Hexachlorofen; Hexachlorofen [Czech]; Hexachlorophen; Hexachlorophene; Hexachlorophenum [INN-Latin]; Hexaclorofeno [INN-Spanish]; Hexafen; Hexaphene-LV; Hexide; Hexophene; Hexosan; Hilo Cat Flea Powder; Hilo Flea Powder; Methane, bis(2,3,5-trichloro-6-hydroxyphenyl)-; Nabac; Nabac 25 EC; Neosept V; Pedigree Dog Shampoo Bar; Phenol, 2,2'-methylenebis(3,4,6-trichloro)-; Phenol, 2,2'-methylenebis(3,4,6-trichloro-; Phenol, 2,2'-methylenebis(3,5,6-trichloro-; Phisodan; Ritosept; Septisol; Septofen; Solu-Heks; Staphene O; Ster-Zac; Steral; Steraskin; Surgi-Cen; Surgi-cin; Surofene; Tersaseptic; Thera-Groom Pet Shampoo for Dogs for Veterinary Use Only; Trichlorophene; Trisophen; Turgex; pHisoHex; [ChemIDplus] UN2875
Category
Biocides/Disinfectants
Description
White to light tan, crystalline powder; [HSDB]
Sources/Uses
Used as an antibacterial agent, disinfectant, fungicide, and acaricide; [HSDB]
Comments
Hexachlorophene was removed from the over-the-counter market in the 1970s after neurotoxic effects were reported. Studies showed that between 0.3% and 6% of photo patch tested patients were allergic to this substance. [Marks, p. 232-3] Asthma reported in hospital employee; [Malo] In high-dose animal studies, hexachlorophene causes testicular damage and birth defects. [Frazier, p. 271-2] Acute exposure may cause CNS effects; A skin sensitizer; May cause asthma; [ICSC]
Biomedical References

Exposure Assessment

Vapor Pressure
8.3E-11 mm Hg
Lethal Concentration
LC50 (rat) = 340 mg/m3
Explanatory Notes
VP from HSDB;
Reference Link #2

Adverse Effects

Skin Sensitizer
Yes
Asthma
Yes
Neurotoxin
Other CNS neurotoxin
Reproductive Toxin
Yes
IARC Carcinogen
Not classifiable

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: