Agent Name
CAS Number
Major Category
Folpet formula graphical representation
Cosan T; Faltan; Folnit; Folpel; Ftalan; Fungitrol 11; Intercide TMP; Orthophaltan 50; Orthophaltan; Phthaltan; Sanfol; Spolacid; Trifol; Folpan; Folpex; Phaltan; Vinicoll; Thiophal; [EXTOXNET] 2-((Trichloromethyl)thio)-1H-isoindole-1,3(2H)-dione; Acryptan; Cosan I; ENT 26539; Faltex; Folpel [French]; Fungitrol; Fungitrol II; Murphy's rose fungicide; N-(Trichlor-methylthio)-phthalamid [German]; N-(Trichlormethylthio)phthalimide; N-(Trichloromethanesulphenyl)phthalimide; N-(Trichloromethylthio)phthalimide; Ortho phaltan 50W; Orthophaltan; Phthaltan; Spolacid; Trichlormethylthioimid kyseliny ftalove [Czech]; Trichloromethylthiophthalimide; Troysan anti-mildew O; 1H-Isoindole-1,3(2H)-dione, 2-((trichloromethyl)thio)-; Phthalimide, N-((trichloromethyl)thio)-; [ChemIDplus]
Colorless or white solid; [HSDB] White solid; Technical product is off-white to tan solid; [Reference #2]
Primarily used as an agricultural fungicide, but some industrial uses (paints and plastics); [ACGIH] The thiophthalimides are widely used fungicides on seeds, field crops, and stored produce; [EPA Pesticides] Used as a biocide in paints; [Adams, p. 475] Used in the USA as a pesticide on avocados and as a wood preservative; used in Europe on grapes; [Zainal h, Shane S, Que H. Flopet Permeation Through Nitrile Gloves. Appl Occup Environ Hyg 2003;18:658-668] Used in the US as fungicide for avocados, paints, caulking compounds, and wood treatments; [Reference #2] Used in the EU as fungicide for winter wheat, tomatoes, and wine grapes; [EFSA]
A skin sensitizer in guinea pigs; Sensitization not reported in humans despite wide-scale use; TLV Basis is liver damage and body weight effects; [ACGIH] The thiophthalimides include captan, captafol, and folpet. No systemic poisonings in humans have been reported. [EPA Pesticides] An eye irritant; May cause skin sensitization; Can be absorbed through skin; [ICSC] Rapidly forms the short-lived and highly reactive metabolite thiophosgene in the presence of thiols in tissue and blood; [Reference #2] Birth defects observed at very high doses in one study of hamsters, although negative results seen in studies of mice, rats, rabbits, and monkeys; [REPROTOX] A severe eye irritant and skin sensitizer; No evidence of toxicity to fertility or reproduction in a 2-generation study of rats, but teratogenic effects observed in rabbits; Not genotoxic in vivo but carcinogenic in mice; [EFSA]
Reference Link #1
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
1 mg/m3, inhalable particulate matter
Vapor Pressure
1.57E-07 mm Hg
Lethal Concentration
LC50 (rat) = 480 mg/m3
Explanatory Notes
VP from HSDB;
Reference Link #2

Adverse Effects

Skin Sensitizer
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
ACGIH Carcinogen
Confirmed Animal

Diseases, Processes, and Activities Linked to This Agent


Occupational diseases associated with exposure to this agent: